Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice

• Main Authors: Othman, MA, Yuyama, Kohei, Murai, Yuta, Igarashi, Yasuyuki, Mikami, Daisuke, Yasodha Sivasothy, *, Khalijah Awang,, Monde, Kenji
• Format: Article
• Language: English
• Published: American Chemical Society 2019
• Subjects: QD Chemistry
• Online Access: http://eprints.sunway.edu.my/1122/1/Yasodha%20ACS%20Medicinal%20Chemistry%20Letter-accepted%202019.pdf; http://eprints.sunway.edu.my/1122/; http://doi.org/10.1021/acsmedchemlett.9b00171

The interaction between natural occurring inhibitors and targeted membrane proteins could be an alternative medicinal strategy for the treatment of metabolic syndrome, notably, obesity. In this study, we identified malabaricones A–C and E (1–4) isolated from the fruits of Myristica cinnamomea King a...