Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice
The interaction between natural occurring inhibitors and targeted membrane proteins could be an alternative medicinal strategy for the treatment of metabolic syndrome, notably, obesity. In this study, we identified malabaricones A–C and E (1–4) isolated from the fruits of Myristica cinnamomea King a...
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my.sunway.eprints.11222019-11-15T01:56:52Z http://eprints.sunway.edu.my/1122/ Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice Othman, MA Yuyama, Kohei Murai, Yuta Igarashi, Yasuyuki Mikami, Daisuke Yasodha Sivasothy, * Khalijah Awang, Monde, Kenji QD Chemistry The interaction between natural occurring inhibitors and targeted membrane proteins could be an alternative medicinal strategy for the treatment of metabolic syndrome, notably, obesity. In this study, we identified malabaricones A–C and E (1–4) isolated from the fruits of Myristica cinnamomea King as natural inhibitors for sphingomyelin synthase (SMS), a membrane protein responsible for sphingolipid biosynthesis. Having the most promising inhibition, oral administration of compound 3 exhibited multiple efficacies in reducing weight gain, improving glucose tolerance, and reducing hepatic steatosis in high fat diet-induced obesity mice models. Liver lipid analysis revealed a crucial link between the SMS activities of compound 3 and its lipid metabolism in vitro and in vivo. The nontoxic nature of compound 3 makes it a suitable candidate in search of drugs which can be employed in the treatment and prevention of obesity. American Chemical Society 2019-07-03 Article PeerReviewed text en cc_by_nc_nd_4 http://eprints.sunway.edu.my/1122/1/Yasodha%20ACS%20Medicinal%20Chemistry%20Letter-accepted%202019.pdf Othman, MA and Yuyama, Kohei and Murai, Yuta and Igarashi, Yasuyuki and Mikami, Daisuke and Yasodha Sivasothy, * and Khalijah Awang, and Monde, Kenji (2019) Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice. ACS Medicinal Chemistry Letters, 10 (8). pp. 1154-1158. ISSN 1948-5875 http://doi.org/10.1021/acsmedchemlett.9b00171 doi:10.1021/acsmedchemlett.9b00171 |
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QD Chemistry Othman, MA Yuyama, Kohei Murai, Yuta Igarashi, Yasuyuki Mikami, Daisuke Yasodha Sivasothy, * Khalijah Awang, Monde, Kenji Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice |
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The interaction between natural occurring inhibitors and targeted membrane proteins could be an alternative medicinal strategy for the treatment of metabolic syndrome, notably, obesity. In this study, we identified malabaricones A–C and E (1–4) isolated from the fruits of Myristica cinnamomea King as natural inhibitors for sphingomyelin synthase (SMS), a membrane protein responsible for sphingolipid biosynthesis. Having the most promising inhibition, oral administration of compound 3 exhibited multiple efficacies in reducing weight gain, improving glucose tolerance, and reducing hepatic steatosis in high fat diet-induced obesity mice models. Liver lipid analysis revealed a crucial link between the SMS activities of compound 3 and its lipid metabolism in vitro and in vivo. The nontoxic nature of compound 3 makes it a suitable candidate in search of drugs which can be employed in the treatment and prevention of obesity. |
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Othman, MA Yuyama, Kohei Murai, Yuta Igarashi, Yasuyuki Mikami, Daisuke Yasodha Sivasothy, * Khalijah Awang, Monde, Kenji |
author_facet |
Othman, MA Yuyama, Kohei Murai, Yuta Igarashi, Yasuyuki Mikami, Daisuke Yasodha Sivasothy, * Khalijah Awang, Monde, Kenji |
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Othman, MA |
title |
Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice |
title_short |
Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice |
title_full |
Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice |
title_fullStr |
Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice |
title_full_unstemmed |
Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice |
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malabaricone c as natural sphingomyelin synthase inhibitor against diet-induced obesity and its lipid metabolism in mice |
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American Chemical Society |
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2019 |
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http://eprints.sunway.edu.my/1122/1/Yasodha%20ACS%20Medicinal%20Chemistry%20Letter-accepted%202019.pdf http://eprints.sunway.edu.my/1122/ http://doi.org/10.1021/acsmedchemlett.9b00171 |
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