A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism

• Main Authors: Phei, Felicia Lin Lim, Tan, Khai Ching, Luna, Giuseppe, Tiekink, Edward R. T. *, Dolzhenko, Anton V
• Format: Article
• Language: English
• Published: Elsevier 2019
• Subjects: QD Chemistry
• Online Access: http://eprints.sunway.edu.my/1021/1/Tiekink%20A%20New%20Practical%20Synthesis%20of%203-amino%20Tetrahedron%202019%2075%202314_acc.pdf; http://eprints.sunway.edu.my/1021/; https://doi.org/10.1016/j.tet.2019.03.003

It was found that 3-amino-substituted 5-aminopyrazoles could be effectively prepared via hydrolytic decarboxylation of the corresponding 3,5-diaminopyrazole-4-carboxylates 5 under microwave irradiation. The reactions required short time (4 min) and were successfully reproduced in a larger scale and...