Synthesis of 3-(5-amino-1H-1,2,4-triazol-3-yl) propanamides and their tautomerism

• Main Authors: Lim, Felicia Phei Lin, Tan, Lin Yuing, Tiekink, Edward R. T. *, Dolzhenko, Anton V
• Format: Article
• Language: English
• Published: Royal Society of Chemistry 2018
• Subjects: QD Chemistry
• Online Access: http://eprints.sunway.edu.my/846/1/Tiekink%20Synthesis%20of%203-5.pdf; http://eprints.sunway.edu.my/846/; http://www.rsc.li/rsc-advances

Two complementary pathways for the preparation of N-substituted 3-(5-amino-1H-1,2,4-triazol-3-yl) propanamides (5) were proposed and successfully realized in the synthesis of 20 representative examples. These methods use the same types of starting materials viz. succinic anhydride, aminoguanidine...