Insights into the structure and drug design of benzimidazole derivatives targeting the epidermal growth factor receptor (EGFR)

• Main Authors: Abdullah, Mar'iyah Najihah, Ali, Yousaf, Abd Hamid, Shafida
• Format: Article
• Language: English
• Published: Wiley 2022
• Subjects: QD Chemistry; RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/95763/1/95763_Insights%20into%20the%20structure%20and%20drug%20design.pdf; http://irep.iium.edu.my/95763/; https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13974

Tyrosine kinase overexpression could result in an unfavourable consequence of cancer progression in the body. A number of kinase inhibitor drugs targeting various cancer-related protein kinases have been developed and proven successful in clinical therapy. Benzimidazole is one of the most studied...