Engineering human epidermal growth receptor 2‑Targeting hepatitis B virus core nanoparticles for siRNA delivery in vitro and in vivo

• Main Authors: Mohamed Suffian, Izzat Fahimuddin, Wang, Julie Tzu-Wen, Faruqu, Farid Nazer, Benitez, Julio, Nishimura, Yuya, Ogino, Chiaki, Akihiko, Kondo, Al-Jamal, Khuloud
• Format: Article
• Language: English
• Published: American Chemical Society 2018
• Subjects: RM147 Administration of Drugs and Other Therapeutic Agents; RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/64619/1/acsanm.8b00480.pdf; http://irep.iium.edu.my/64619/; https://pubs.acs.org/doi/pdf/10.1021/acsanm.8b00480

Hepatitis B virus core (HBc) particles acquire the capacity to disassemble and reassemble in a controlled manner, allowing entrapment and delivery of drugs and macromolecules to cells. HBc particles are made of 180−240 copies of 21 kDa protein monomers, assembled into 30−34 nm diameter icosahedral...