Quantitative description of publications (1986-2020) related to Alzheimer disease and oxidative stress: a bibliometric study

• Main Authors: Qaid, Entesar Yasin Abdo, Long, Idris, Azman, Khairunnuur Fairuz, Ahmad, Asmah Hayati, Othman, Zahiruddin, Kuttulebbai Naina Mohamed Salam, Sirajudeen, Ahmi, Aidi, Zakaria, Rahimah
• Format: Article
• Language: English
• Published: Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği 2021
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/93046/8/93046_Quantitative%20description%20of%20publications%20%281986-2020%29.pdf; http://irep.iium.edu.my/93046/; https://dergipark.org.tr/en/download/article-file/1802910

While the pathological mechanism of Alzheimer’s Disease (AD) is unclear, oxidative stress has been proposed to be one of its related theories, which can help to uncover the disease’s pathological factors. This review aims to provide a quantitative description and data visualisation of AD and oxidative stress research from the literature obtained from the Scopus database. Based on the keywords used, which are related to AD and oxidative stress in the article title, 996 documents were retrieved for further analysis. Microsoft Excel, VOSviewer and Harzing’s Publish or Perish were used to conduct the frequency analysis, data visualisation, and citation analysis. There is a continuous growth in the number of publications on research in AD and oxidative stress, starting from 1986 and spanning 35 years. The most cited article was “Oxidative stress hypothesis in Alzheimer's disease”. The Journal of Alzheimer Disease published the most number of publications related to AD and oxidative stress, while the United States and its institutions were the main contributors. Our findings suggest that research on aetiopathology, biomarkers and neuroprotective agents for AD dominated this research field. Our bibliometric analysis provides distinct trends in AD and oxidative stress research in the last 35 years. Our findings highlight current hot topics related to biomarkers for screening and diagnosis of AD as well as neuroprotective agents used as disease-modifying therapies of AD