The impact of carbamazepine crystallinity on carbamazepine-loaded microparticle formulations
Crystallinity plays a vital role in the pharmaceutical industry. It affects drug manufacturing, development processes, and the stability of pharmaceutical dosage forms. An objective of this study was to measure and analyze the carbamazepine (CBZ) crystallinity before and after formulation. Moreove...
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Main Authors: | , , , |
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Format: | Article |
Language: | English English |
Published: |
Elsevier
2021
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Subjects: | |
Online Access: | http://irep.iium.edu.my/90815/7/90815_The%20impact%20of%20carbamazepine%20crystallinity%20on%20carbamazepine-loaded_SCOPUS.pdf http://irep.iium.edu.my/90815/8/90815_The%20impact%20of%20carbamazepine%20crystallinity%20on%20carbamazepine-loaded.pdf http://irep.iium.edu.my/90815/ https://www.sciencedirect.com/science/article/abs/pii/S0378517321004439 |
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Summary: | Crystallinity plays a vital role in the pharmaceutical industry. It affects drug manufacturing, development processes,
and the stability of pharmaceutical dosage forms. An objective of this study was to measure and analyze
the carbamazepine (CBZ) crystallinity before and after formulation. Moreover, it intended to determine the
extent to which the crystallinity of CBZ would affect the drug loading, the particle size, and the release of CBZ
from the microparticles. The CBZ microparticles were prepared by encapsulating CBZ in ethyl cellulose (EC)
polymer using a solvent evaporation method. EC was used here as a release modifier polymer and polyvinyl
alcohol (PVA) as an aqueous phase stabilizer. Factorial design was used to prepare the CBZ microparticle formulations,
including polymer concentration, solvent (dichloromethane, ethyl acetate), PVA concentrations factor,
the homogenization time, and homogenization speed. The crystallinity of CBZ was calculated utilizing
differential scanning calorimetry (DSC) thermal analysis. The crystallinity was calculated from the enthalpy of
CBZ. Enthalpy was analyzed from the area under the curve peak of CBZ standard and CBZ-loaded microparticles.
DSC and ATR-FTIR assessed the possible interaction between CBZ and excipients in the microparticle. The
prepared CBZ microparticles showed various changes in the crystallinity rate of CBZ. The changes in the rate of
CBZ crystallinity had different effects on the particle size, the drug loading, and the release of CBZ from the
polymer. Statistically, all studied factors significantly affected the crystallinity of CBZ after formulation to
microparticles. |
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