The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients
Introduction: The roots of E. longifolia jack (E.L.) or Tongkat Ali have been used in traditional medicine as well as supplements and food additives. Many chemical compounds have been detected in extracts of its roots which are believed to be responsible for its medicinal properties. In this stud...
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Pharmacognosy Network Worldwide
2021
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my.iium.irep.905342021-07-08T08:09:55Z http://irep.iium.edu.my/90534/ The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients Ramzi, Muhamad Iyad Kosnin, Muhammad Hazzim Faisal, Ghasak Ghazi Mohd Hafiz, Arzmi Kusumawardani, Anisa Sabere, Awis Sukarni Mohmad Makkey, Essam A Ibrahim, Omar Emad R Medicine (General) RB Pathology Introduction: The roots of E. longifolia jack (E.L.) or Tongkat Ali have been used in traditional medicine as well as supplements and food additives. Many chemical compounds have been detected in extracts of its roots which are believed to be responsible for its medicinal properties. In this study, our objectives were to study the effects of EL root extracts on the growth of Streptococcus Mutans, Lactobacillus and Candida Albicans isolated from saliva of adult patients with high caries risk. Materials and Methods: The ethanolic extract of the root of this plant was tested against saliva isolated Streptococcus Mutans, Lactobacillus and Candida Albicans via disc diffusion assay at a concentration of 200mg/mL. The minimum inhibitory concentration was carried out by the standard broth microdilution method. Cell viability of test microorganisms against different concentration of the extract and inhibition zones were calculated. Results: Disk diffusion assay showed positive zones of inhibition for all test microorganisms with S. mutans, Lactobacillus and C. albicans exhibiting zones of inhibition of 8.3 ± 0.7mm, 12.4 ± 2.4mm and 21.4 ± 2.7mm respectively. For minimum inhibitory concentration, the test microorganisms were tested at concentration of 250mg/ mL, 125mg/mL, 62.5mg/mL, 31.3mg/mL and 0mg/mL. The minimum inhibitory concentration showed that MIC of S. mutans was at 62.5mg/mL, Lactobacillus at 125mg/mL and C. albicans at 31.3mg/mL. Lastly, the cell viability results supported the MIC determined prior. Conclusion: Ethanol-based E. longifolia Jack root extract has an antimicrobial effect on the following microorganisms isolated from the saliva of high-risk caries adult patients: S. mutans, Lactobacillus and C. albicans. Pharmacognosy Network Worldwide 2021-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/90534/7/90534_The%20effect%20of%20eurycoma%20longifolia%20jack.pdf application/pdf en http://irep.iium.edu.my/90534/13/90534_The%20effect%20of%20eurycoma%20longifolia%20jack_SCOPUS.pdf Ramzi, Muhamad Iyad and Kosnin, Muhammad Hazzim and Faisal, Ghasak Ghazi and Mohd Hafiz, Arzmi and Kusumawardani, Anisa and Sabere, Awis Sukarni Mohmad and Makkey, Essam A and Ibrahim, Omar Emad (2021) The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients. Pharmacognosy journal, 13 (3). pp. 787-791. ISSN 0975-3575 http://www.phcogj.com/sites/default/files/PharmacognJ-13-3-787.pdf http://dx.doi.org/10.5530/pj.2021.13.100 |
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R Medicine (General) RB Pathology Ramzi, Muhamad Iyad Kosnin, Muhammad Hazzim Faisal, Ghasak Ghazi Mohd Hafiz, Arzmi Kusumawardani, Anisa Sabere, Awis Sukarni Mohmad Makkey, Essam A Ibrahim, Omar Emad The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients |
description |
Introduction: The roots of E. longifolia jack (E.L.) or Tongkat Ali have been used in traditional
medicine as well as supplements and food additives. Many chemical compounds have
been detected in extracts of its roots which are believed to be responsible for its medicinal
properties. In this study, our objectives were to study the effects of EL root extracts on the
growth of Streptococcus Mutans, Lactobacillus and Candida Albicans isolated from saliva of
adult patients with high caries risk. Materials and Methods: The ethanolic extract of the
root of this plant was tested against saliva isolated Streptococcus Mutans, Lactobacillus and
Candida Albicans via disc diffusion assay at a concentration of 200mg/mL. The minimum
inhibitory concentration was carried out by the standard broth microdilution method. Cell
viability of test microorganisms against different concentration of the extract and inhibition
zones were calculated. Results: Disk diffusion assay showed positive zones of inhibition
for all test microorganisms with S. mutans, Lactobacillus and C. albicans exhibiting zones
of inhibition of 8.3 ± 0.7mm, 12.4 ± 2.4mm and 21.4 ± 2.7mm respectively. For minimum
inhibitory concentration, the test microorganisms were tested at concentration of 250mg/
mL, 125mg/mL, 62.5mg/mL, 31.3mg/mL and 0mg/mL. The minimum inhibitory concentration
showed that MIC of S. mutans was at 62.5mg/mL, Lactobacillus at 125mg/mL and C.
albicans at 31.3mg/mL. Lastly, the cell viability results supported the MIC determined prior.
Conclusion: Ethanol-based E. longifolia Jack root extract has an antimicrobial effect on the
following microorganisms isolated from the saliva of high-risk caries adult patients: S. mutans,
Lactobacillus and C. albicans. |
format |
Article |
author |
Ramzi, Muhamad Iyad Kosnin, Muhammad Hazzim Faisal, Ghasak Ghazi Mohd Hafiz, Arzmi Kusumawardani, Anisa Sabere, Awis Sukarni Mohmad Makkey, Essam A Ibrahim, Omar Emad |
author_facet |
Ramzi, Muhamad Iyad Kosnin, Muhammad Hazzim Faisal, Ghasak Ghazi Mohd Hafiz, Arzmi Kusumawardani, Anisa Sabere, Awis Sukarni Mohmad Makkey, Essam A Ibrahim, Omar Emad |
author_sort |
Ramzi, Muhamad Iyad |
title |
The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients |
title_short |
The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients |
title_full |
The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients |
title_fullStr |
The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients |
title_full_unstemmed |
The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients |
title_sort |
effect of eurycoma longifolia jack (tongkat ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients |
publisher |
Pharmacognosy Network Worldwide |
publishDate |
2021 |
url |
http://irep.iium.edu.my/90534/7/90534_The%20effect%20of%20eurycoma%20longifolia%20jack.pdf http://irep.iium.edu.my/90534/13/90534_The%20effect%20of%20eurycoma%20longifolia%20jack_SCOPUS.pdf http://irep.iium.edu.my/90534/ http://www.phcogj.com/sites/default/files/PharmacognJ-13-3-787.pdf http://dx.doi.org/10.5530/pj.2021.13.100 |
_version_ |
1705056522196746240 |
score |
13.18916 |