The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients
Introduction: The roots of E. longifolia jack (E.L.) or Tongkat Ali have been used in traditional medicine as well as supplements and food additives. Many chemical compounds have been detected in extracts of its roots which are believed to be responsible for its medicinal properties. In this stud...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Pharmacognosy Network Worldwide
2021
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/90534/7/90534_The%20effect%20of%20eurycoma%20longifolia%20jack.pdf http://irep.iium.edu.my/90534/13/90534_The%20effect%20of%20eurycoma%20longifolia%20jack_SCOPUS.pdf http://irep.iium.edu.my/90534/ http://www.phcogj.com/sites/default/files/PharmacognJ-13-3-787.pdf http://dx.doi.org/10.5530/pj.2021.13.100 |
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| Summary: | Introduction: The roots of E. longifolia jack (E.L.) or Tongkat Ali have been used in traditional
medicine as well as supplements and food additives. Many chemical compounds have
been detected in extracts of its roots which are believed to be responsible for its medicinal
properties. In this study, our objectives were to study the effects of EL root extracts on the
growth of Streptococcus Mutans, Lactobacillus and Candida Albicans isolated from saliva of
adult patients with high caries risk. Materials and Methods: The ethanolic extract of the
root of this plant was tested against saliva isolated Streptococcus Mutans, Lactobacillus and
Candida Albicans via disc diffusion assay at a concentration of 200mg/mL. The minimum
inhibitory concentration was carried out by the standard broth microdilution method. Cell
viability of test microorganisms against different concentration of the extract and inhibition
zones were calculated. Results: Disk diffusion assay showed positive zones of inhibition
for all test microorganisms with S. mutans, Lactobacillus and C. albicans exhibiting zones
of inhibition of 8.3 ± 0.7mm, 12.4 ± 2.4mm and 21.4 ± 2.7mm respectively. For minimum
inhibitory concentration, the test microorganisms were tested at concentration of 250mg/
mL, 125mg/mL, 62.5mg/mL, 31.3mg/mL and 0mg/mL. The minimum inhibitory concentration
showed that MIC of S. mutans was at 62.5mg/mL, Lactobacillus at 125mg/mL and C.
albicans at 31.3mg/mL. Lastly, the cell viability results supported the MIC determined prior.
Conclusion: Ethanol-based E. longifolia Jack root extract has an antimicrobial effect on the
following microorganisms isolated from the saliva of high-risk caries adult patients: S. mutans,
Lactobacillus and C. albicans. |
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