Optimization of supercritical fluid extraction of asiaticoside from Centella Asiatica using Central Composite Design (CCD)
The extraction of asiaticoside was performed using supercritical fluid extraction to produce highly concentrated extracts. The effects of three factors (co-solvent percentage, pressure, and tempera- ture) on the asiaticoside content were screened using the Two-Level Factorial design and optimized us...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor and Francis
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/84851/1/Optimization%20of%20supercritical%20fluid%20extraction%20of%20asiaticoside%20from%20Centella%20asiatica%20using%20Central%20Composite%20Design%20CCD.pdf http://irep.iium.edu.my/84851/ https://www.tandfonline.com/doi/full/10.1080/01496395.2020.1845208 |
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| Summary: | The extraction of asiaticoside was performed using supercritical fluid extraction to produce highly concentrated extracts. The effects of three factors (co-solvent percentage, pressure, and tempera- ture) on the asiaticoside content were screened using the Two-Level Factorial design and optimized using the Central Composite Design. Asiaticoside was extracted following the treatment combina- tions of three parameters, namely co-solvent (5–15%), temperature (70–90°C), and pressure (1–20 MPa). The optimized extraction parameters were identified at 10%, 10.5 MPa, and 80°C for co- solvent percentage, pressure, and temperature, respectively. |
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