Generation of functioning nephrons by implanting human pluripotent stem cell-derived kidney progenitors

• Main Authors: Bantounas, Ioannis, Ranjzad, Parisa, Tengku Zakaria, Tengku Muhamad Faris Syafiq, Silajdžić, Edina, Forster, Duncan, Asselin, Marie-Claude, Lewis, Philip, Lennon, Rachel, Plagge, Antonius, Wang, Qi, Woolf, Adrian S., Kimber, Susan J.
• Format: Article
• Language: English
• Published: Elsevier 2018
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/84383/1/Generation%20of%20Functioning%20Nephrons%20by%20Implanting%20Human%20Pluripotent%20Stem%20Cell-Derived%20Kidney%20Progenitors.pdf; http://irep.iium.edu.my/84383/; https://pubmed.ncbi.nlm.nih.gov/29429961/

Human pluripotent stem cells (hPSCs) hold great promise for understanding kidney development and disease. We reproducibly differentiated three genetically distinct wild-type hPSC lines to kidney precursors that underwent rudimentary morphogenesis in vitro. They expressed nephron and collecting duct...