Periodic assessment of (ET-1) and Nitric Oxide (NO) in hypertensive disorders of pregnancy (HDP)

• Main Authors: Ismawi, Hidayatul Radziah, Abdul Razak, Tariq, Jamani, Nurjasmine Aida, Mohd Zainudin, Maizura
• Format: Conference or Workshop Item
• Language: English; English
• Published: 2019
• Subjects: RC Internal medicine; RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System; RG Gynecology and obstetrics; RG551 Pregnancy
• Online Access: http://irep.iium.edu.my/83592/1/FAOPS%202019%20EDITED%20poster%2090x190cm.pdf; http://irep.iium.edu.my/83592/17/FAOPS2019_Programbook.pdf; http://irep.iium.edu.my/83592/

INTRODUCTION Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in both essential hypertension and HDP. Disturbances in Nitric Oxide (NO) bioavailability found in endothelial dysfunction may increase susceptibility to cardiovascular diseases. METHODOLOGY Thirty six pregnant women at 30-36 weeks period of gestation from the following categories (i) pregnancy induced hypertension (PIH) (ii) chronic hypertension during pregnancy (CH) and (iii) normal pregnant women (Control). Blood pressure indices measurements and sample collection was done at antepartum (30-36 weeks), post partum (8 weeks and 12 weeks). Endothelin-1 and serum NO were measured using the Human ET-1 (Endothelin-1) and NO ELISA Kit. RESULTS All blood pressure indices were significantly higher in HDP patients compared to control during antenatal and post partum periods. Serum ET-1 was significantly higher in patients with HDP compared to control during antenatal until 3 months post partum. This was accompanied by significantly lower levels of serum NO in HDP patients. CONCLUSION Persistently high levels of ET-1 and low levels of NO up to 3 months post partum in patients with history of HDP indicate presence of persistent endothelial dysfunction despite BP normalisation in PIH patients. Long term NO/ET-1 imbalance may account for the increased CVS disease risk.