Comparison of disintegrant-addition methods on the compounding of orodispersible tablets
Orodispersible tablets disintegrate rapidly (within 3 minutes) in the oral cavity and release the medicament before swal- lowing. The mode of disintegrant addition might affect the properties of orodispersible tablets. The objective of this study was to formulate and evaluate orodispersible t...
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International Journal of Pharmaceutical Compounding
2020
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my.iium.irep.825702020-09-10T08:22:04Z http://irep.iium.edu.my/82570/ Comparison of disintegrant-addition methods on the compounding of orodispersible tablets Mahesparan, Vishnu Abd Razak, Fashli Syafiq Long, Chiau Ming Abul Bashar Mohammed, Helaluddin Sarker, Md Zaidul Islam Liew, Kai Bin QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Orodispersible tablets disintegrate rapidly (within 3 minutes) in the oral cavity and release the medicament before swal- lowing. The mode of disintegrant addition might affect the properties of orodispersible tablets. The objective of this study was to formulate and evaluate orodispersible tablets by studying different modes of disintegration addition with varying concentrations of disintegrants. The wet granulation method was used to produce the orodispersible tablets. Two methods of disintegration addition were compared (i.e., intragranular, extragranular). Three disintegrants (i.e., corn- starch, sodium starch glycolate, crospovidone) were used at three levels (5%, 10%, and 15%) in the study. The formula- tions were tested for the powder flowability (angle of repose) and characterized physically (hardness, weight, thickness, friability, disintegration time). The mangosteen pericarp extract was used as a model active pharmaceutical ingredient to be incorporated into the optimum formulation. It was observed that the extragranular method produced granules with better flowability compared to that of the intragranular method. Crospovidone was found as the most efficient disintegrant among the three. The optimum formu- lation selected was one with the highest concentration of crospovidone (15%), which showed the fastest disintegration time. The mode of disintegrant addition into the orodispers- ible tablets formulation was found to show a marked differ- ence in the disintegration, as well as other physical characteristics of the orodispersible tablets where the extra- granular mode of addition showed better property, which caused the orodispersible tablets to disintegrate the fastest. International Journal of Pharmaceutical Compounding 2020-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/82570/1/Comparison%20Disintegrant-Addi%20Methods%20Orodispersible%20Table....pdf application/pdf en http://irep.iium.edu.my/82570/7/82570_Comparison%20of%20disintegrant-addition%20methods%20on%20the%20compounding%20of%20orodispersible%20tablets.pdf Mahesparan, Vishnu and Abd Razak, Fashli Syafiq and Long, Chiau Ming and Abul Bashar Mohammed, Helaluddin and Sarker, Md Zaidul Islam and Liew, Kai Bin (2020) Comparison of disintegrant-addition methods on the compounding of orodispersible tablets. International Journal of Pharmaceutical Compounding, 24 (2). pp. 148-155. ISSN 1092-4221 https://ijpc.com/Products/#Articles |
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QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Mahesparan, Vishnu Abd Razak, Fashli Syafiq Long, Chiau Ming Abul Bashar Mohammed, Helaluddin Sarker, Md Zaidul Islam Liew, Kai Bin Comparison of disintegrant-addition methods on the compounding of orodispersible tablets |
description |
Orodispersible tablets disintegrate rapidly (within 3 minutes)
in the oral cavity and release the medicament before swal-
lowing. The mode of disintegrant addition might affect the
properties of orodispersible tablets. The objective of this
study was to formulate and evaluate orodispersible tablets
by studying different modes of disintegration addition with
varying concentrations of disintegrants. The wet granulation
method was used to produce the orodispersible tablets. Two
methods of disintegration addition were compared (i.e.,
intragranular, extragranular). Three disintegrants (i.e., corn-
starch, sodium starch glycolate, crospovidone) were used at
three levels (5%, 10%, and 15%) in the study. The formula-
tions were tested for the powder flowability (angle of
repose) and characterized physically (hardness, weight,
thickness, friability, disintegration time). The mangosteen
pericarp extract was used as a model active pharmaceutical
ingredient to be incorporated into the optimum formulation.
It was observed that the extragranular method produced
granules with better flowability compared to that of the
intragranular method. Crospovidone was found as the most
efficient disintegrant among the three. The optimum formu-
lation selected was one with the highest concentration of
crospovidone (15%), which showed the fastest disintegration
time. The mode of disintegrant addition into the orodispers-
ible tablets formulation was found to show a marked differ-
ence in the disintegration, as well as other physical
characteristics of the orodispersible tablets where the extra-
granular mode of addition showed better property, which
caused the orodispersible tablets to disintegrate the fastest. |
format |
Article |
author |
Mahesparan, Vishnu Abd Razak, Fashli Syafiq Long, Chiau Ming Abul Bashar Mohammed, Helaluddin Sarker, Md Zaidul Islam Liew, Kai Bin |
author_facet |
Mahesparan, Vishnu Abd Razak, Fashli Syafiq Long, Chiau Ming Abul Bashar Mohammed, Helaluddin Sarker, Md Zaidul Islam Liew, Kai Bin |
author_sort |
Mahesparan, Vishnu |
title |
Comparison of disintegrant-addition methods on
the compounding of orodispersible tablets |
title_short |
Comparison of disintegrant-addition methods on
the compounding of orodispersible tablets |
title_full |
Comparison of disintegrant-addition methods on
the compounding of orodispersible tablets |
title_fullStr |
Comparison of disintegrant-addition methods on
the compounding of orodispersible tablets |
title_full_unstemmed |
Comparison of disintegrant-addition methods on
the compounding of orodispersible tablets |
title_sort |
comparison of disintegrant-addition methods on
the compounding of orodispersible tablets |
publisher |
International Journal of Pharmaceutical Compounding |
publishDate |
2020 |
url |
http://irep.iium.edu.my/82570/1/Comparison%20Disintegrant-Addi%20Methods%20Orodispersible%20Table....pdf http://irep.iium.edu.my/82570/7/82570_Comparison%20of%20disintegrant-addition%20methods%20on%20the%20compounding%20of%20orodispersible%20tablets.pdf http://irep.iium.edu.my/82570/ https://ijpc.com/Products/#Articles |
_version_ |
1677780719858876416 |
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13.160551 |