Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases

• Main Authors: Mansor, Nur Izzati, Nordin, Norshariza, Mohamed, Farahidah, Ling, King-Hwa, Rosli, Rozita, Hassan, Zurina
• Format: Article
• Language: English; English; English
• Published: Bentham Science Publishers 2019
• Subjects: RS192 Materia Medica-Pharmaceutical Technology
• Online Access: http://irep.iium.edu.my/79799/19/79799_Crossing%20the%20Blood-Brain%20Barrier_article_new.pdf; http://irep.iium.edu.my/79799/2/79799_Crossing%20the%20Blood-Brain%20Barrier_scopus.pdf; http://irep.iium.edu.my/79799/3/79799_Crossing%20the%20Blood-Brain%20Barrier_wos.pdf; http://irep.iium.edu.my/79799/; http://www.eurekaselect.com/node/174513/article/crossing-the-blood-brain-barrier-a-review-on-drug-delivery-strategies-for-treatment-of-the-central-nervous-system-diseases

Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to target sites in the brain. The principles of drug d...