Cover Image

Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor

The present study aimed to characterize and investigate 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one (22) as a novel selective COX-2 inhibitor. The data collected from the single X-ray crystallographic analysis and in silico study provide important insights on the molecular...

Full description

Saved in:
Bibliographic Details
Main Authors: Rullah, Kamal, Mohd Aluwi, Mohd Fadhlizil Fasihi, M.Yamin, Bohari, Baharuddin, Mohd Syukri, Ismail, Nor Hadiani, YudaTeruna, Hilwan, Abbas Bukhari, Syed Nasir, Jantan, Ibrahim, Jalil, Juriyati, Husain, Khairana, Lam, Kok Wai
Format: Article
Language:English
Published: Elsevier 2015
Subjects:
RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:http://irep.iium.edu.my/73535/1/Kamal%20Rullah%204.pdf
http://irep.iium.edu.my/73535/
https://www.sciencedirect.com/science/article/abs/pii/S0022286014010059
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.73535
record_format dspace
spelling my.iium.irep.735352019-08-07T03:18:28Z http://irep.iium.edu.my/73535/ Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor Rullah, Kamal Mohd Aluwi, Mohd Fadhlizil Fasihi M.Yamin, Bohari Baharuddin, Mohd Syukri Ismail, Nor Hadiani YudaTeruna, Hilwan Abbas Bukhari, Syed Nasir Jantan, Ibrahim Jalil, Juriyati Husain, Khairana Lam, Kok Wai RS403 Materia Medica-Pharmaceutical Chemistry The present study aimed to characterize and investigate 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one (22) as a novel selective COX-2 inhibitor. The data collected from the single X-ray crystallographic analysis and in silico study provide important insights on the molecular conformation and the binding interactions that are responsible for the COX-2 selectivity. Elsevier 2015-02-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/73535/1/Kamal%20Rullah%204.pdf Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and M.Yamin, Bohari and Baharuddin, Mohd Syukri and Ismail, Nor Hadiani and YudaTeruna, Hilwan and Abbas Bukhari, Syed Nasir and Jantan, Ibrahim and Jalil, Juriyati and Husain, Khairana and Lam, Kok Wai (2015) Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor. Journal of Molecular Structure, 1081. pp. 51-61. ISSN 0022-2860 https://www.sciencedirect.com/science/article/abs/pii/S0022286014010059 10.1016/j.molstruc.2014.10.004
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle RS403 Materia Medica-Pharmaceutical Chemistry
Rullah, Kamal
Mohd Aluwi, Mohd Fadhlizil Fasihi
M.Yamin, Bohari
Baharuddin, Mohd Syukri
Ismail, Nor Hadiani
YudaTeruna, Hilwan
Abbas Bukhari, Syed Nasir
Jantan, Ibrahim
Jalil, Juriyati
Husain, Khairana
Lam, Kok Wai
Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor
description The present study aimed to characterize and investigate 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one (22) as a novel selective COX-2 inhibitor. The data collected from the single X-ray crystallographic analysis and in silico study provide important insights on the molecular conformation and the binding interactions that are responsible for the COX-2 selectivity.
format Article
author Rullah, Kamal
Mohd Aluwi, Mohd Fadhlizil Fasihi
M.Yamin, Bohari
Baharuddin, Mohd Syukri
Ismail, Nor Hadiani
YudaTeruna, Hilwan
Abbas Bukhari, Syed Nasir
Jantan, Ibrahim
Jalil, Juriyati
Husain, Khairana
Lam, Kok Wai
author_facet Rullah, Kamal
Mohd Aluwi, Mohd Fadhlizil Fasihi
M.Yamin, Bohari
Baharuddin, Mohd Syukri
Ismail, Nor Hadiani
YudaTeruna, Hilwan
Abbas Bukhari, Syed Nasir
Jantan, Ibrahim
Jalil, Juriyati
Husain, Khairana
Lam, Kok Wai
author_sort Rullah, Kamal
title Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor
title_short Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor
title_full Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor
title_fullStr Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor
title_full_unstemmed Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor
title_sort molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4h-chromen-4-one as a novel selective cox-2 inhibitor
publisher Elsevier
publishDate 2015
url http://irep.iium.edu.my/73535/1/Kamal%20Rullah%204.pdf
http://irep.iium.edu.my/73535/
https://www.sciencedirect.com/science/article/abs/pii/S0022286014010059
_version_ 1643620339615268864
score 13.188404

Similar Items