Papillary thyroid cancer: Genetic alterations and molecular biomarker investigations

• Main Authors: Abdullah, Mardiaty Iryani, Mat Junit, Sarni, Khoon, Leong Ng, Jayapalan, Jaime Jacqueline, Karikalan, Barani, Hashim, Onn
• Format: Article
• Language: English; English; English
• Published: Ivyspring International Publisher 2019
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/72650/1/72650_Papillary%20Thyroid%20Cancer.pdf; http://irep.iium.edu.my/72650/2/72650_Papillary%20Thyroid%20Cancer_SCOPUS.pdf; http://irep.iium.edu.my/72650/13/72650_Papillary%20Thyroid%20Cancer_wos.pdf; http://irep.iium.edu.my/72650/; http://www.medsci.org/v16p0450.pdf

Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent, with less than 2% mortality at 5 years. However, more than 25% of patients with PTC developed a recurrence during a long term follow-up. The present article provides an updated condensed overview of PTC, which focuses mainly on the molecular alterations involved and recent biomarker investigations.