Malignant transformation of benign thyroid nodule is caused by prolonged H2O2 insult that interfered with the STAT3 pathway?

• Main Authors: Lee, Ching Chin, Abdullah, Mardiaty Iryani, Mat Junit, Sarni, Ng, Khoon Leong, Wong, Sing Ying, Ramli, Nur Siti Fatimah, Hashim, Onn
• Format: Article
• Language: English; English
• Published: e-Century Publishing Corporation 2016
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/92924/7/92924_Malignant%20transformation%20of%20benign%20thyroid%20nodule_SCOPUS.pdf; http://irep.iium.edu.my/92924/8/92924_Malignant%20transformation%20of%20benign%20thyroid%20nodule.pdf; http://irep.iium.edu.my/92924/; http://www.ijcem.com/files/ijcem0026448.pdf

Approximately 60% of papillary thyroid cancer (PTC) cases in Malaysia occur as a result of long-standing benign thyroid nodules. However, the underlying mechanisms that led to the malignant transformation are not understood. Methods & Results: Here, we report a study of benign and malignant thyr...