Analogues of 2-Deoxyglucose as inhibitor candidates for hexokinase II identified via virtual screening analyses

• Main Authors: Tanbin, Suriyea, Ogu Salim, Nurhainis, Ahmad Fuad, Fazia Adyani
• Format: Conference or Workshop Item
• Language: English
• Published: Kulliyyah of Engineering, International Islamic University Malaysia 2018
• Subjects: TP248.13 Biotechnology
• Online Access: http://irep.iium.edu.my/70506/1/70506_Analogues%20of%202-Deoxyglucose%20as%20Inhibitor%20Candidates.pdf; http://irep.iium.edu.my/70506/; http://www.iium.edu.my/icbioe/2018/

Dengue fever is one of the major global health issues, yet specific treatment remains vague. The human hexokinase isoform II (HK2) is one of the crucial enzyme for dengue virus (DENV) replication and thus has been suggested as a potential therapeutic target for DENV drug development. In this paper...