Identifying analogues of 2-deoxyglucose, alpha-d-glucose and beta-d-glucose-6-phosphate as potential inhibitors of human hexokinase ii for the development of anti-dengue therapeutics

• Main Authors: Tanbin, Suriyea, Ogu Salim, Nurhainis, Ahmad Fuad, Fazia Adyani
• Format: Article
• Language: English; English; English
• Published: Universiti Putra Malaysia Press 2019
• Subjects: TP Chemical technology; TP248.13 Biotechnology
• Online Access: http://irep.iium.edu.my/79647/1/79647_Identifying%20Analogues%20Of%202-Deoxyglucose.pdf; http://irep.iium.edu.my/79647/2/79647_Identifying%20Analogues%20Of%202-Deoxyglucose_SCOPUS.pdf; http://irep.iium.edu.my/79647/3/79647_Identifying%20Analogues%20Of%202-Deoxyglucose_WOS.pdf; http://irep.iium.edu.my/79647/; http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2027%20(4)%20Oct.%202019/11%20JST-1644-2019.pdf

The human hexokinase isoform II (HKII) is one of the important enzymes for dengue virus (DENV) replication and thus has been suggested as a potential therapeutic target for DENV drug development. In this work, compounds were identified using Ultrafast Shape Recognition with CREDO Atom Types (USRCAT)...