The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions
Previous reports from this laboratory have shown that flavonoids including apigenin are capable of inducing oxidative DNA cleavage in the presence of copper ions. In the present report, we have examined the ability of amentoflavone, a biflavonoid which is a dimer of apigenin, to catalyze the degrada...
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my.iium.irep.689362019-01-02T00:12:43Z http://irep.iium.edu.my/68936/ The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions Ahmed, Qamar Uddin Malik, Arshi Azam, Sonish Hadi, Naghma Azmi, Asfar Sohail Parveen, Nazneen Khan, Nizam Ud Din Hadi, Sheikh Mumtaz Q Science (General) Previous reports from this laboratory have shown that flavonoids including apigenin are capable of inducing oxidative DNA cleavage in the presence of copper ions. In the present report, we have examined the ability of amentoflavone, a biflavonoid which is a dimer of apigenin, to catalyze the degradation of DNA. Amentoflavone was found to degrade calf thymus DNA in the presence of Cu(II) at a rate almost twice that of apigenin. Amentoflavone was also shown to reduce Cu(II) to Cu(I) and to generate hydroxyl radicals in the presence of copper ions. In the presence of Cu(II), the absorption spectrum of amentoflavone undergoes a shift and a quenching effect indicating that the biflavonoid is capable of binding to copper ions. Amentoflavone and apigenin were isolated from Cycas rumphii and Trifolium alexandrinum, respectively. The results are discussed in relation to the putative chemopreventive mechanism of amentoflavone. Elsevier Science 2004 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68936/1/Toxicology%20in%20vitro_The_biflavonoid_amentoflavone_degrades_D.pdf Ahmed, Qamar Uddin and Malik, Arshi and Azam, Sonish and Hadi, Naghma and Azmi, Asfar Sohail and Parveen, Nazneen and Khan, Nizam Ud Din and Hadi, Sheikh Mumtaz (2004) The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions. Toxicology in Vitro, 18 (4). pp. 435-440. ISSN 0887-2333 10.1016/j.tiv.2003.12.009 |
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Q Science (General) Ahmed, Qamar Uddin Malik, Arshi Azam, Sonish Hadi, Naghma Azmi, Asfar Sohail Parveen, Nazneen Khan, Nizam Ud Din Hadi, Sheikh Mumtaz The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions |
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Previous reports from this laboratory have shown that flavonoids including apigenin are capable of inducing oxidative DNA cleavage in the presence of copper ions. In the present report, we have examined the ability of amentoflavone, a biflavonoid which is a dimer of apigenin, to catalyze the degradation of DNA. Amentoflavone was found to degrade calf thymus DNA in the presence of Cu(II) at a rate almost twice that of apigenin. Amentoflavone was also shown to reduce Cu(II) to Cu(I) and to generate hydroxyl radicals in the presence of copper ions. In the presence of Cu(II), the absorption spectrum of amentoflavone undergoes a shift and a quenching effect indicating that the biflavonoid is capable of binding to copper ions. Amentoflavone and apigenin were isolated from Cycas rumphii and Trifolium alexandrinum, respectively. The results are discussed in relation to the putative chemopreventive mechanism of amentoflavone. |
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Article |
author |
Ahmed, Qamar Uddin Malik, Arshi Azam, Sonish Hadi, Naghma Azmi, Asfar Sohail Parveen, Nazneen Khan, Nizam Ud Din Hadi, Sheikh Mumtaz |
author_facet |
Ahmed, Qamar Uddin Malik, Arshi Azam, Sonish Hadi, Naghma Azmi, Asfar Sohail Parveen, Nazneen Khan, Nizam Ud Din Hadi, Sheikh Mumtaz |
author_sort |
Ahmed, Qamar Uddin |
title |
The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions |
title_short |
The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions |
title_full |
The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions |
title_fullStr |
The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions |
title_full_unstemmed |
The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions |
title_sort |
biflavonoids, amentoflavone degrades calf thymus dna in the presence of copper ions |
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Elsevier Science |
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2004 |
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http://irep.iium.edu.my/68936/1/Toxicology%20in%20vitro_The_biflavonoid_amentoflavone_degrades_D.pdf http://irep.iium.edu.my/68936/ |
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1643618683757527040 |
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13.18916 |