Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum

• Main Authors: Awang, Anis Fadhlina Izyani, Ahmed, Qamar Uddin, Ali Shah, Syed Adnan, Md. Jaffri, Juliana, Ghafoor, Kashif, Helal Uddin, A.B.M., Ferdosh, Sahena, Sarker, Md. Zaidul Islam
• Format: Article
• Language: English; English; English
• Published: Taylors & Francis 2020
• Subjects: QD Chemistry; RS Pharmacy and materia medica; RS192 Materia Medica-Pharmaceutical Technology; RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/68100/19/Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound%20from%20an%20untapped%20plant%20Stereospermum%20fimbriatum.pdf; http://irep.iium.edu.my/68100/25/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_Scopus.pdf; http://irep.iium.edu.my/68100/26/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_WOS.pdf; http://irep.iium.edu.my/68100/; https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1494170?journalCode=gnpl20

Stereospermum fimbriatum or locally known as “ Chicha ” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum ’ s stem bark against 11 pathogens and isolate its bioactive compound. Successive soxhlet extraction was conducted using n-hexane, dichloromethane DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum ’ s extract. The DCM extract of stem bark(DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 m g/mL to 6.25 m g/mL, against S. epidermidis,MRSA and S. aureus. Thus, S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections,specifically, MRSA.