FOXRED1 silencing in mice: a possible animal model for leigh syndrome.

• Main Authors: Mohamed, Salama, El-Desouky, Sara, Alsayed, Aziza, El-Hussiny, Mahmoud, Moustafa, Abdelrahman, Taalab, Yasmeen M., Mohamed, Wael Mohamed Yousef
• Format: Article
• Language: English; English; English
• Published: Springer New York LLC 2019
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/67455/19/67455_FOXRED1%20silencing%20in%20mice_complete.pdf; http://irep.iium.edu.my/67455/7/67455_FOXRED1%20silencing%20in%20mice_SCOPUS.pdf; http://irep.iium.edu.my/67455/8/67455_FOXRED1%20silencing%20in%20mice_WOS.pdf; http://irep.iium.edu.my/67455/; https://link.springer.com/article/10.1007/s11011-018-0334-z

Leigh syndrome (LS) is one of the most puzzling mitochondrial disorders, which is also known as subacute necrotizing encephalopathy. It has an incidence of 1 in 77,000 live births worldwide with poor prognosis. Currently, there is a poor understanding of the underlying pathophysiological mechanisms...