Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance.

• Main Authors: Ahmada, Sheikh Fayaz, Zoheir, Khairy M.A., Ansari, Mushtaq Ahmad, Korashya, Hesham M., Bakheet, Saleh A., Ashour, Abdelkader Elbadawy Abbas, Attiaa,, Sabry M.
• Format: Article
• Language: English; English
• Published: Elsevier 2015
• Subjects: RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/66949/1/Stimulation%20of%20the%20histamine%204%20receptor%20with%204-methylhistamine%20modulates%20the%20effects%20of%20chronic%20stress%20on%20the%20Th1%20Th2%20cytokine%20balance.pdf; http://irep.iium.edu.my/66949/7/66949_Scopus%20-%20Document%20details.pdf; http://irep.iium.edu.my/66949/; https://www.elsevier.com/journals/personal/immunobiology/0171-2985

Alterations to the immune system caused by stress have been considered to markedly increase the risk for immune-related diseases such as cancer and autoimmune disorders. We investigated the potential anti-stress effects of the histamine 4 receptor (H4R) agonist, 4-methylhistamine (4-MeH), in a murin...