Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma

• Main Authors: Higuchi, Hiroshi, Yamakawa, Natsuko, Imadome, Ken Ichi, Yahata, Takashi, Kotaki, Ryutaro, Ogata, Jun, Kakizaki, Masatoshi, Fujita, Koji, Lu, Jun, Yokoyama, Kazuaki, Okuyama, Kazuki, Sato, Ai, Takamatsu, Masako, Kurosaki, Natsumi, Mohamad Alba, Syakira, Azhim, Azran, Horie, Ryouichi, Watanabe, Toshiki, Kitamura, Toshio, Ando, Kiyoshi, Kashiwagi, Takao, Matsui, Toshimitsu, Okamoto, Akinao, Handa, Hiroshi, Kuroda, Masahiko, Nakamura, Naoya
• Format: Article
• Language: English; English; English
• Published: American Society of Hematology 2018
• Subjects: Q Science (General); QR Microbiology; RC Internal medicine
• Online Access: http://irep.iium.edu.my/65992/1/65992_Role%20of%20exosomes%20as%20a%20proinflammatory_article.pdf; http://irep.iium.edu.my/65992/2/65992_Role%20of%20exosomes%20as%20a%20proinflammatory_scopus.pdf; http://irep.iium.edu.my/65992/13/65992%20Role%20of%20exosomes%20as%20a%20proinflammatory%20mediator%20in%20the%20development%20of%20EBV-associated%20lymphoma_wos.pdf; http://irep.iium.edu.my/65992/; http://www.bloodjournal.org/content/131/23/2552?sso-checked=true

Epstein-Barr virus (EBV) causes various diseases in the elderly, including B-cell lymphoma such as Hodgkin's lymphoma and diffuse large B-cell lymphoma. Here, we show that EBV acts in trans on noninfected macrophages in the tumor through exosome secretion and augments the development of lymphom...