A simple method for extracting both active oily and water soluble extract (WSE) from Nigella sativa (L.) seeds using a single solvent system
The current study provides a way of extraction for both active NSO and WSE from Nigella sativa seeds using 98% methanol. About 1 kg of ground seeds was macerated by 1:2.5 w/v (g/mL) for 72 hours. After rotary evaporation and 7 days of continuous drying and chilling at 50 and 4 °C, NSO and WSE were o...
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Taylor and Francis
2018
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my.iium.irep.651082020-04-09T14:23:11Z http://irep.iium.edu.my/65108/ A simple method for extracting both active oily and water soluble extract (WSE) from Nigella sativa (L.) seeds using a single solvent system Babar, Z.M. Wan Sulaiman, Wan Mohd. Azizi Arief Ichwan, Solachuddin Jauhari Ahmed, Qamar Uddin Azad, Abul Kalam Mawa, Imranul Q Science (General) The current study provides a way of extraction for both active NSO and WSE from Nigella sativa seeds using 98% methanol. About 1 kg of ground seeds was macerated by 1:2.5 w/v (g/mL) for 72 hours. After rotary evaporation and 7 days of continuous drying and chilling at 50 and 4 °C, NSO and WSE were obtained at the same instant. Solubility tests of 24 solvents and 11 thin layer chromatographic analyses while 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging assay of NSO (73.66) , WSE (33.32) and NSO + WSE (78.22) against ascorbic acid (IC50 = 4.28 mg/mL) was performed. WSE was found to be highly soluble in water and 5% NaOH exhibiting the same Rf value of 0.95 for EtOH:DMSO (9:1) against the honey. WSE has revealed more than twofold higher anti-oxidant activity than others. Formulation of WSE with Tualang honey may provide better targeted hydrophilic drug delivery systems. Taylor and Francis 2018-07-24 Article PeerReviewed application/pdf en http://irep.iium.edu.my/65108/16/65108-A%20simple%20method%20for%20extracting%20both%20active%20oily%20-article%20for%20myra.pdf application/pdf en http://irep.iium.edu.my/65108/9/65108%20A%20simple%20method%20for%20extracting%20both%20active%20oily%20and%20water%20soluble%20extract%20SCOPUS-in-press.pdf application/pdf en http://irep.iium.edu.my/65108/17/65108_A%20simple%20method%20for%20extracting%20both%20active%20oily_wos.pdf Babar, Z.M. and Wan Sulaiman, Wan Mohd. Azizi and Arief Ichwan, Solachuddin Jauhari and Ahmed, Qamar Uddin and Azad, Abul Kalam and Mawa, Imranul (2018) A simple method for extracting both active oily and water soluble extract (WSE) from Nigella sativa (L.) seeds using a single solvent system. Natural Product Research. pp. 1-6. ISSN 1478-6419 E-ISSN 1478-6427 (In Press) https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1493587 10.1080/14786419.2018.1493587587 |
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Q Science (General) Babar, Z.M. Wan Sulaiman, Wan Mohd. Azizi Arief Ichwan, Solachuddin Jauhari Ahmed, Qamar Uddin Azad, Abul Kalam Mawa, Imranul A simple method for extracting both active oily and water soluble extract (WSE) from Nigella sativa (L.) seeds using a single solvent system |
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The current study provides a way of extraction for both active NSO and WSE from Nigella sativa seeds using 98% methanol. About 1 kg of ground seeds was macerated by 1:2.5 w/v (g/mL) for 72 hours. After rotary evaporation and 7 days of continuous drying and chilling at 50 and 4 °C, NSO and WSE were obtained at the same instant. Solubility tests of 24 solvents and 11 thin layer chromatographic analyses while 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging assay of NSO (73.66) , WSE (33.32) and NSO + WSE (78.22) against ascorbic acid (IC50 = 4.28 mg/mL) was performed. WSE was found to be highly soluble in water and 5% NaOH exhibiting the same Rf value of 0.95 for EtOH:DMSO (9:1) against the honey. WSE has revealed more than twofold higher anti-oxidant activity than others. Formulation of WSE with Tualang honey may provide better targeted hydrophilic drug delivery systems. |
format |
Article |
author |
Babar, Z.M. Wan Sulaiman, Wan Mohd. Azizi Arief Ichwan, Solachuddin Jauhari Ahmed, Qamar Uddin Azad, Abul Kalam Mawa, Imranul |
author_facet |
Babar, Z.M. Wan Sulaiman, Wan Mohd. Azizi Arief Ichwan, Solachuddin Jauhari Ahmed, Qamar Uddin Azad, Abul Kalam Mawa, Imranul |
author_sort |
Babar, Z.M. |
title |
A simple method for extracting both active oily and water soluble extract (WSE) from Nigella sativa (L.) seeds using a single solvent system |
title_short |
A simple method for extracting both active oily and water soluble extract (WSE) from Nigella sativa (L.) seeds using a single solvent system |
title_full |
A simple method for extracting both active oily and water soluble extract (WSE) from Nigella sativa (L.) seeds using a single solvent system |
title_fullStr |
A simple method for extracting both active oily and water soluble extract (WSE) from Nigella sativa (L.) seeds using a single solvent system |
title_full_unstemmed |
A simple method for extracting both active oily and water soluble extract (WSE) from Nigella sativa (L.) seeds using a single solvent system |
title_sort |
simple method for extracting both active oily and water soluble extract (wse) from nigella sativa (l.) seeds using a single solvent system |
publisher |
Taylor and Francis |
publishDate |
2018 |
url |
http://irep.iium.edu.my/65108/16/65108-A%20simple%20method%20for%20extracting%20both%20active%20oily%20-article%20for%20myra.pdf http://irep.iium.edu.my/65108/9/65108%20A%20simple%20method%20for%20extracting%20both%20active%20oily%20and%20water%20soluble%20extract%20SCOPUS-in-press.pdf http://irep.iium.edu.my/65108/17/65108_A%20simple%20method%20for%20extracting%20both%20active%20oily_wos.pdf http://irep.iium.edu.my/65108/ https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1493587 |
_version_ |
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13.19449 |