In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds

• Main Authors: Mohammed Babar, Zahir Uddin, Jaswir, Irwandi, Tareq, Abu Montakim, Ali Reza, A. S. M., Wan Sulaiman, Wan Mohd Azizi, Mahamad Maifiah, Mohd Hafidz, Ahfter, F., Hasan, Md Imran, Farhad, Saif, Uddin, Md. Rokib, Ichwan, Solachuddin J. A., Ahmed, Qamar Uddin, Bakhtiar, M. Taher, Mawa, Imranul
• Format: Article
• Language: English; English; English
• Published: Taylor & Francis Online 2019
• Subjects: QD Chemistry; RS403 Materia Medica-Pharmaceutical Chemistry; S Agriculture (General)
• Online Access: http://irep.iium.edu.my/75208/1/75208_In%20vivo%20anxiolytic%20and%20in%20vitro.pdf; http://irep.iium.edu.my/75208/2/75208_In%20vivo%20anxiolytic%20and%20in%20vitro_SCOPUS%20in%20press.pdf; http://irep.iium.edu.my/75208/3/75208_In%20vivo%20anxiolytic%20and%20in%20vitro_WOS%20in%20press.pdf; http://irep.iium.edu.my/75208/; https://doi.org/10.1080/14786419.2019.1667348

The WSE is a highly polar, gummy and mucilaginous bioactive content of the Nigella sativa (L.) seeds. This study reports the anxiolytic and anti-inflammatory effects of WSE investigated using Elevated Plus Maze (EPM) and Hole-Board Test (HBT) in adult mice and human RBCs haemolysis inhibition and pr...