Apoptotic induction in CCRF-CEM and HL-60 human leukemic cell lines by 5-Azacitidine and trichostatin A.

• Main Authors: Aziee, Sudin, Haiyuni, Mohd Yassim, Nagi Al-Jamal, Hamid Ali, Shafini, Mohamed Yusoff, Abdul Wahab, Ridhwan, Shamsuddin, Shaharum, Johan, Muhammad Farid
• Format: Article
• Language: English
• Published: Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia. 2018
• Subjects: RM147 Administration of Drugs and Other Therapeutic Agents
• Online Access: http://irep.iium.edu.my/69651/1/69651_Apoptotic%20Induction%20in%20CCRF-CEM.pdf; http://irep.iium.edu.my/69651/; http://apps.amdi.usm.my/journal/index.php/jbcs/article/view/160

The aims of the study were to investigate the anti-cancer effects of 5Aza and TSA in two leukemic cell lines (CCRF-CEM and HL-60). Inhibition concentration of 5-Aza and TSA were measured using trypan blue exclusion assay. 5-Aza and TSA at IC50 were treated to both CCRF-CEM and HL-60 cell lines for 4...