Investigating the potential of Nigella sativa and thymoquinone in salvaging the embryo from effects of toxic paternal exposure to cyclophosphamide

• Main Authors: Abdul Rahman, Suzanah, Abdul Samat, Nadia Hanis, Ahmad, Nur Amalina, Abdullah, Afif Raihan, Mohamad Zahri, Syazana, Kamarzaman, Saheera
• Format: Article
• Language: English; English
• Published: International Islamic University Malaysia 2017
• Subjects: Q Science (General); QD Chemistry; RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/62941/1/62941_Investigating%20the%20Potential%20of%20Nigella%20Sativa_article.pdf; http://irep.iium.edu.my/62941/2/62941_Investigating%20the%20Potential%20of%20Nigella%20Sativa_scopus.pdf; http://irep.iium.edu.my/62941/; https://pdfs.semanticscholar.org/8121/8af5ee07e3d75b3b9a0510bb81e967ab1bad.pdf

Background: Exposure to cyclophosphamide (CPA) for cancer treatment results in over-production of reactive oxygen species causes oxidative stress thus affecting the DNA in male germ cell inducing sperm defects. Our goal is to assess the potential effects of Nigella sativa extract (NSE) and thymoqu...