Prediction of clinical symptoms of schizophrenia based on COMT methylation marker

• Main Authors: Abd. Rahim, Nour El Huda, Rahim, Mohd Nabil Fikri, Ku Zaifah, Norsidah, Mohd Noor, Hanisah, Abdullah, Kartini, A. Talib, Norlelawati
• Format: Conference or Workshop Item
• Language: English; English
• Published: Kulliyyah of Medicine, International Islamic University Malaysia 2017
• Subjects: RC Internal medicine; RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
• Online Access: http://irep.iium.edu.my/59599/1/Abstract%20ID2%20Poster%20MRS2017.pdf; http://irep.iium.edu.my/59599/2/HUDA%20MRS%20POSTER%201.pdf; http://irep.iium.edu.my/59599/; http://iiumedic.net/imjm/v1/download/Volume%2015%20Supplement/MRS2016-ABSTRACT-BOOK-86.pdf

Introduction: The dopamine hypothesis of schizophrenia is based on the fact that hyper-dopaminergic state is involved in causing psychosis and antipsychotic drugs block the dopamine receptor. COMT regulates the homeostatic levels of neurotransmitter dopamine in the synapses and plays a role in the n...