Imbalanced expression of polycistronic miRNA in acute myeloid leukemia

• Main Authors: Kotaki, Ryutaro, Higuchi, Hiroshi, Ogiya, Daisuke, Katahira, Yasuhiro, Kurosaki, Natsumi, Yukihira, Naoko, Ogata, Jun, Yamamoto, Haruna, Mohamad Alba, Syakira, Azhim, Azran, Kitajima, Tatsuo, Inoue, Shigeaki, Morishita, Kazuhiro, Ono, Koh, Koyama-Nasu, Ryo, Kotani, Ai
• Format: Article
• Language: English; English
• Published: Springer International Publishing AG 2017
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/58944/1/10.1007%40s12185-017-2314-1.pdf; http://irep.iium.edu.my/58944/7/Imbalanced%20expression%20of%20polycistronic%20miRNA%20in%20acute%20myeloid%20leukemia.pdf; http://irep.iium.edu.my/58944/; https://link.springer.com/article/10.1007/s12185-017-2314-1

miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It...