Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties

• Main Authors: Bozdag, Murat, Alafeefy, Ahmed Mahmoud, Carta, Fabrizio, Ceruso, Mariangela, Al-Tamimi, Abdul-Malek S., Al-Kahtani, Abdulla A., Alasmary, Fatmah A.S., Supuran, Claudiu T.
• Format: Article
• Language: English; English; English
• Published: Elsevier 2016
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/51705/1/2016_4100-4107.pdf; http://irep.iium.edu.my/51705/4/51705_benzenesulfonamides%20with%20subnanomolar%20carbonic_Scopus.pdf; http://irep.iium.edu.my/51705/5/51705_benzenesulfonamides%20with%20subnanomolar%20carbonic_WoS.pdf; http://irep.iium.edu.my/51705/; http://www.sciencedirect.com/science/article/pii/S0968089616304758

Condensation of substituted anthranilic acids with 4-isothiocyanatoethyl-benzenesulfonamide led to series of heterocyclic benzenesulfonamides incorporating 2-mercapto-quinazolin-4-one tails. These sulfonamides were investigated as inhibitors of the human carbonic anhydrase (hCA, EC 4.2.1.1) isofor...