Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity

• Main Authors: Bozdag, Murat, Alafeefy, Ahmed Mahmoud, Altamimi, Abdul Malik, Vullo, Daniela, Carta, Fabrizio, Supuran,, Claudiu T.
• Format: Article
• Language: English; English; English
• Published: Elsevier Ltd 2017
• Subjects: Q Science (General); RC Internal medicine; RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/56574/1/56574_Coumarins%20and%20other%20fused%20bicyclic_text.pdf; http://irep.iium.edu.my/56574/2/56574_Coumarins%20and%20other%20fused%20bicyclic_SCOPUS.pdf; http://irep.iium.edu.my/56574/13/56574_Coumarins%20and%20other%20fused%20bicyclic%20heterocycles_WOS.pdf; http://irep.iium.edu.my/56574/; http://www.sciencedirect.com/science/article/pii/S0968089616311051

Herein we report for the first time a series of 2-benzamido-N-(2-oxo-4-(methyl/trifluoromethyl)-2H-chromen-7-yl) benzamide 3a–f and substituted quinazolin-4(3H)-ones and 2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxides (5, 6, 8 and 10a–c) as selective inhibitors of the tumor associated hCA IX and...