Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations

• Main Authors: Abd Halim, Khairul Bariyyah, Koldsoe, Heidi, Sansom, Mark S.P.
• Format: Article
• Language: English
• Published: Elsevier 2015
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/47685/1/KB_Abd_Halim.pdf; http://irep.iium.edu.my/47685/; http://www.ncbi.nlm.nih.gov/pubmed/25219456

The epidermal growth factor receptor (EGFR) is the best characterised member of the receptor tyrosine kinases, which play an important role in signalling across mammalian cell membranes. The EGFR juxtamembrane (JM) domain is involved in the mechanism of activation of the receptor, interacting with t...