Cover Image

Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations

The epidermal growth factor receptor (EGFR) is the best characterised member of the receptor tyrosine kinases, which play an important role in signalling across mammalian cell membranes. The EGFR juxtamembrane (JM) domain is involved in the mechanism of activation of the receptor, interacting with t...

Full description

Saved in:
Bibliographic Details
Main Authors: Abd Halim, Khairul Bariyyah, Koldsoe, Heidi, Sansom, Mark S.P.
Format: Article
Language:English
Published: Elsevier 2015
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/47685/1/KB_Abd_Halim.pdf
http://irep.iium.edu.my/47685/
http://www.ncbi.nlm.nih.gov/pubmed/25219456
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.47685
record_format dspace
spelling my.iium.irep.476852017-10-26T07:23:47Z http://irep.iium.edu.my/47685/ Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations Abd Halim, Khairul Bariyyah Koldsoe, Heidi Sansom, Mark S.P. QD Chemistry The epidermal growth factor receptor (EGFR) is the best characterised member of the receptor tyrosine kinases, which play an important role in signalling across mammalian cell membranes. The EGFR juxtamembrane (JM) domain is involved in the mechanism of activation of the receptor, interacting with the anionic lipid phosphatidylinositol 4,5-bisphosphate (PIP2) in the intracellular leaflet of the cell membrane.Multiscale MD simulations were used to characterize PIP2-JM interactions. Simulations of the transmembrane helix plus JM region (TM-JM) dimer (PDB:2M20) in both PIP2-containing and PIP2-depleted lipid bilayer membranes revealed the interactions of the JM with PIP2 and other lipids. Elsevier 2015-05 Article REM application/pdf en cc_by http://irep.iium.edu.my/47685/1/KB_Abd_Halim.pdf Abd Halim, Khairul Bariyyah and Koldsoe, Heidi and Sansom, Mark S.P. (2015) Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations. Biochimica et Biophysica Acta, 1850 (5). pp. 1017-1025. ISSN 0304-4165 http://www.ncbi.nlm.nih.gov/pubmed/25219456 doi:10.1016/j.bbagen.2014.09.006
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Abd Halim, Khairul Bariyyah
Koldsoe, Heidi
Sansom, Mark S.P.
Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
description The epidermal growth factor receptor (EGFR) is the best characterised member of the receptor tyrosine kinases, which play an important role in signalling across mammalian cell membranes. The EGFR juxtamembrane (JM) domain is involved in the mechanism of activation of the receptor, interacting with the anionic lipid phosphatidylinositol 4,5-bisphosphate (PIP2) in the intracellular leaflet of the cell membrane.Multiscale MD simulations were used to characterize PIP2-JM interactions. Simulations of the transmembrane helix plus JM region (TM-JM) dimer (PDB:2M20) in both PIP2-containing and PIP2-depleted lipid bilayer membranes revealed the interactions of the JM with PIP2 and other lipids.
format Article
author Abd Halim, Khairul Bariyyah
Koldsoe, Heidi
Sansom, Mark S.P.
author_facet Abd Halim, Khairul Bariyyah
Koldsoe, Heidi
Sansom, Mark S.P.
author_sort Abd Halim, Khairul Bariyyah
title Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
title_short Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
title_full Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
title_fullStr Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
title_full_unstemmed Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
title_sort interactions of the egfr juxtamembrane domain with pip2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
publisher Elsevier
publishDate 2015
url http://irep.iium.edu.my/47685/1/KB_Abd_Halim.pdf
http://irep.iium.edu.my/47685/
http://www.ncbi.nlm.nih.gov/pubmed/25219456
_version_ 1643613239732338688
score 13.160551

Similar Items