Population pharmacokinetics of doripenem in critically ill patients with sepsis in a Malaysian intensive care unit

• Main Authors: Abdul Aziz, Mohd. Hafiz, Abd. Rahman, Nurul Azrin, Mat Nor, Mohd Basri, Sulaiman, Helmi, Wallis, Steven C., Lipman, Jeffrey, Roberts, Jason A., Staatz, Christine E.
• Format: Article
• Language: English; English
• Published: American Society for Microbiolog 2016
• Subjects: QR Microbiology; RM300 Drugs and their action; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/46664/4/46664_Population_Pharmacokinetics_WOS_Scopus.pdf; http://irep.iium.edu.my/46664/6/Item_ID_46664.pdf; http://irep.iium.edu.my/46664/; http://aac.asm.org/content/early/2015/10/13/AAC.01543-15.abstract

Doripenem has been recently introduced in Malaysia and is used for severe infections in the intensive care unit. However, limited data currently exist to guide optimal dosing in this scenario. We aimed to describe the population pharmacokinetics of doripenem in Malaysian critically ill patients with...