Presence of allelic loss and PTEN mutations in malignant gliomas from Malay patients

• Main Authors: Zainuddin, Norafiza, Jaafar, Hasnan, Isa, Mohd. Nizam, Abdullah, Jafri Malin
• Format: Article
• Language: English
• Published: Malaysian Medical Associations 2004
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer); RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
• Online Access: http://irep.iium.edu.my/31130/1/MJM_Malignant_Gliomas.pdf; http://irep.iium.edu.my/31130/; http://www.mma.org.my/Publications/MedicalJournalofMalaysia/tabid/69/Default.aspx

Loss of heterozygosity (LOH) on several loci and mutations on PTEN tumor suppressor gene (10q23.3) occur frequently in sporadic gliomas. We have performed polymerase chain reaction (PCR)-LOH analysis using microsatellite markers and single-stranded conformational polymorphism (SSCP) analysis to dete...