Malignant glioma: The involvement of loss of allelic heterozygosity and PTEN mutations in a group of Malay patients

• المؤلفون الرئيسيون: Zainuddin, Norafiza, Jaafar, Hasnan, Isa, Mohd. Nizam, Abdullah, Jafri Malin
• التنسيق: مقال
• اللغة: English
• منشور في: Faculty of Tropical Medicine, Mahidol University 2005
• الموضوعات: R Medicine (General); RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• الوصول للمادة أونلاين: http://irep.iium.edu.my/28467/1/J_Trop_Med.pdf; http://irep.iium.edu.my/28467/

Frequent loss of heterozygosity (LOH) and mutations of the tumor suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) have been found in sporadic gliomas. The most documented regions of allelic losses include 9p21, 10q23-25 and 17p13 whereas PTEN aberrations are prefere...