Assessment of celecoxib, a selective cox-2 inhibitor, as a neuroprotective agent in alzheimer’s model of rats

• Main Authors: Saxena, Anil Kumar, Noor, Mohd. Fadly, Talib, Norlelawati A.
• Format: Conference or Workshop Item
• Language: English; English
• Published: 2013
• Subjects: RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/29891/1/IRIIE_POSTER_2.pdf; http://irep.iium.edu.my/29891/4/Assessment_of_celecoxib%2C_a_selective_cox-2_inhibitor%2C_as_a_neuroprotective_agent_in_alzheimer%E2%80%99s_model_of_rats.pdf; http://irep.iium.edu.my/29891/; http://www.iium.edu.my/irie/13/index.php/8-iriie/1-iium-research-invention-and-innovation-exhibition-2013

Reduced cerebral blood flow (CBF) has been associated with neurodegenerative disorders including Alzheimer’s disease. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO)...