Straightforward synthesis of novel 1-(2'-α-O-D-glucopyranosyl ethyl) 2-arylbenzimidazoles

• Main Authors: Arumugam, Natarajan, Abdul Rahim, Aisyah Saad, Abd Hamid, Shafida, Osman, Hasnah
• Format: Article
• Language: English
• Published: MDPI 2012
• Subjects: Q Science (General)
• Online Access: http://irep.iium.edu.my/29253/1/Straightforward_Synthesis_of_Novel_1-%282%E2%80%B2-%CE%B1-O-D-Glucopyranosyl.pdf; http://irep.iium.edu.my/29253/; http://www.mdpi.com/1420-3049/17/8/9887

A series of novel 1-(2'-α-O-D-glucopyranosyl ethyl) 2-arylbenzimidazoles has been prepared via one-pot glycosylation of ethyl-1-(2'-hydroxyethyl)-2-arylbenzimidazole-5-carboxylate derivatives. Synthesis of the 2-arylbenzimidazole aglycones from 4-fluoro-3-nitrobenzoic acid was accomplished...