Microwave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative breast cancer cells

• Main Authors: Abdul Rahim, Aisyah Saad, Muhamad Salhimi, Salizawati, Natarajan, Arumugam, Lim, Chung Pin, Ng, Shy Yee, Muttiah, Nithya Niranjini, Wong , Boon Keat, Abd Hamid, Shafida, Osman, Hasnah, Mat, Ishak
• Format: Article
• Language: English
• Published: Informa UK, Ltd. 2013
• Subjects: QD Chemistry; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/29457/4/JEnxInhibition.pdf; http://irep.iium.edu.my/29457/; http://informahealthcare.com/doi/abs/10.3109/14756366.2012.729828

A new series of N-sec/tert-butyl 2-arylbenzimidazole derivatives was synthesised in 85–96% yields within 2–3.5 min by condensing ethyl 3-amino-4-butylamino benzoate with various substituted metabisulfite adducts of benzaldehyde under focused microwave irradiation. The benzimidazole analogues were ch...