Process modelling and debottlenecking study of a vaccine production

• Main Authors: Mohamed Safri, Nurul Huda, Mel, Maizirwan, Foo, Dominic Chwan Yee, K.S. Ng, Denny, M.L. Chew, Irene
• Format: Article
• Language: English
• Published: IIUM Press 2012
• Subjects: TP155 Chemical engineering; TP248.13 Biotechnology
• Online Access: http://irep.iium.edu.my/25806/1/299-1426-1-PB_IEJ_Vol_13-2012.pdf; http://irep.iium.edu.my/25806/; http://iium.edu.my/ejournal/index.php/iiumej/article/viewArticle/299

The main objective of this work is to model and optimise a locallydeveloped Infectious Coryza (IC) vaccine production. The simulation work is performed using a commercial batch process simulator SuperPro Designer v5.5. Six debottlenecking schemes were analysed using throughput analysis and cost to benefit ratio (CBR) when the annual production is increased by 100%. Based on the economic analysis, the selected debottlenecking scheme has annual revenue of USD 240 million, with a gross margin of 9.13% and a return on investment (ROI) of 46.12%. In addition, the payback period of the selected scheme is estimated to be within three years.