Process modelling and debottlenecking study of a vaccine production
The main objective of this work is to model and optimise a locallydeveloped Infectious Coryza (IC) vaccine production. The simulation work is performed using a commercial batch process simulator SuperPro Designer v5.5. Six debottlenecking schemes were analysed using throughput analysis and cost t...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IIUM Press
2012
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/25806/1/299-1426-1-PB_IEJ_Vol_13-2012.pdf http://irep.iium.edu.my/25806/ http://iium.edu.my/ejournal/index.php/iiumej/article/viewArticle/299 |
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| Summary: | The main objective of this work is to model and optimise a locallydeveloped
Infectious Coryza (IC) vaccine production. The simulation work is performed
using a commercial batch process simulator SuperPro Designer v5.5. Six
debottlenecking schemes were analysed using throughput analysis and cost to benefit
ratio (CBR) when the annual production is increased by 100%. Based on the economic
analysis, the selected debottlenecking scheme has annual revenue of USD 240 million,
with a gross margin of 9.13% and a return on investment (ROI) of 46.12%. In addition,
the payback period of the selected scheme is estimated to be within three years. |
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