Anti-inflammatory compounds of macro algae origin: A review
Inflammation, occurs frequently in living tissues, and is responsible for numerous death and precursor to some deadly diseases. This review focus on seaweed derived anti-inflammatory compounds, which have attracted interest and promising replacer of current anti-inflammatory drugs. Macro algae hav...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Academic Journals
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/17155/1/Jaswir_and_Monsur-jmpr_2011.pdf http://irep.iium.edu.my/17155/ http://www.academicjournals.org/JMPR/PDF/pdf2011/31Dec/Jaswir%20and%20Monsur.pdf |
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| Summary: | Inflammation, occurs frequently in living tissues, and is responsible for numerous death and precursor
to some deadly diseases. This review focus on seaweed derived anti-inflammatory compounds, which
have attracted interest and promising replacer of current anti-inflammatory drugs. Macro algae have
both pro- and anti-inflammatory compounds, the later include sulphated polysaccharides (fucoidans)
from brown seaweeds, alkaloids (Caulerpin I, II and III) from red and green seaweeds, polyunsaturated
fatty acids (Docosahexaenoic acid: EDA, Eicosapentaenoic acid: EPA, Stearidonic acid: SA and
Eicosatrienoic acid: ETA), carotenoids (fucoxanthin and astaxanthin), Pheophytin A and Vidalols A and
B. Anti-inflammatory assays include edema, erythema, tumor necrosis factor (TNF-α), interleukin (IL 1β,
6, 8), Nitric oxide (NO), inducible Nitric oxide synthase (iNOS), Prostaglandin E (PGE 2 and 3),
Cyclooxygenase (COX-2), transcription factor (NF-κB) and leukotrienes (LB 3 and 4). Although, in-vivo
and in-vitro studies have been done for crude extracts and specific compounds, but some compounds
have not analysed in-vitro, and investigation of their pathway need to be studied. |
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