Chinese hamster ovary (CHO-K1) cells expressed native insulin-like growth factor-1 (IGF-1) gene towards efficient mammalian cell culture host system

• Main Authors: Packeer Mohamed, Vasila, Hashim, Yumi Zuhanis Has-Yun, Amid, Azura, Mel, Maizirwan, Kamarulzaman, Abdul Razak, Abdul Wahab, Muhammad Adil, Mohmad Saberi, Salfarina Ezrina
• Format: Article
• Language: English
• Published: Academic Journals 2011
• Subjects: TP248.13 Biotechnology
• Online Access: http://irep.iium.edu.my/14207/1/Mohamed_et_al_1.pdf; http://irep.iium.edu.my/14207/; http://www.academicjournals.org/AJB/PDF/pdf2011/16DecConf/Mohamed%20et%20al%201.pdf

Insulin-like growth factor-1 (IGF-1) has been shown to promote cell proliferation and inhibit apoptosis of cells. These are two characteristics of mammalian cell culture which may lead to high density cell culture producing optimal desired yield of bioproducts. An inherent secretion of IGF-1 protei...