Metabolomics combined with chemometric analysis to identify a-glucosidase inhibitors in Phaleria macrocarpa fruit extracts and its molecular docking simulation

• Main Authors: Easmin, Sabina, Islam Sarker, Md. Zaidul, Khatib, Alfi, Ferdosh, Sahena, Jaffri, Juliana, Helal Uddin, A.B.M., Murugesu, Suganya, Balan, Tavamani, Perumal, Vikneswari
• Format: Article
• Language: English; English; English
• Published: Elsevier B.V. 2024
• Subjects: QD Chemistry; RM Therapeutics. Pharmacology; RS Pharmacy and materia medica; RS192 Materia Medica-Pharmaceutical Technology; RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/116596/7/116596_%20Metabolomics%20combined%20with%20chemometric%20analysis%20to%20identify.pdf; http://irep.iium.edu.my/116596/8/116596_%20Metabolomics%20combined%20with%20chemometric%20analysis%20to%20identify_Scopus.pdf; http://irep.iium.edu.my/116596/19/116596_%20Metabolomics%20combined%20with%20chemometric%20analysis%20to%20identify_WoS.pdf; http://irep.iium.edu.my/116596/; http://www.elsevier.com/locate/sajb

Phaleria macrocarpa is a medicinal plant widely available in Malaysia. The plant parts have been traditionally used as an antidiabetic remedy. This study aimed to identify the putative inhibitors of the a-glucosidase enzyme from P. macrocarpa using a gas chromatography-mass spectrometry (GC-MS)-base...