The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review
Maintaining normal polyamine levels is crucial for the physiological cellular process and differentiation because an imbalance of polyamine concentration affects the occurrence of neoplastic activities in many types of cancer diseases. Malaysian herbs have been purported to have anticancer properti...
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Universiti Putra Malaysia
2023
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my.iium.irep.1099542024-05-20T04:34:13Z http://irep.iium.edu.my/109954/ The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review Azalan, Maryam Syahidah Abdul Ghani, Radiah Wallace, Heather M. QP Physiology RM Therapeutics. Pharmacology Maintaining normal polyamine levels is crucial for the physiological cellular process and differentiation because an imbalance of polyamine concentration affects the occurrence of neoplastic activities in many types of cancer diseases. Malaysian herbs have been purported to have anticancer properties that influence the polyamine’s bioavailability, leading to cancer cell death. Presently, the roles of polyamines in Malaysian herbs as chemoprevention have yet to be documented. Thus, this review aims to determine which Malaysian herbs have chemoprevention properties affecting polyamines and appraise the relationship between polyamine levels and Malaysian herbs and their cytotoxicity on cancer cells. The search, employing keywords like “Malaysian herbs”, “polyamines”, and “anticancer” or “chemoprevention”, yielded 256 articles. The articles were screened for their eligibility, befitting the objectives mentioned. The PRISMA-ScR checklist was employed to report the published findings from the databases. Thirteen articles meeting inclusion criteria were selected, highlighting 13 Malaysian herbs influencing the intracellular polyamines pathway. All herbs showed a significant reduction in ornithine decarboxylase (ODC) expression. In addition, Alpinia galanga and Aloe barbadensis showed an increase in catabolic polyamines expression, spermidine/spermine-N-acetyl transferase (SSAT) and spermine oxidase (SMO), respectively, leading to growth arrest and induction of apoptosis in cancer cells. The in vitro and in vivo studies demonstrated these herbs’ anti-proliferative effects on diverse cancer types, involving polyamine level modulation, intracellular dynamics, and chemopreventive mechanisms through apoptosis and anti-inflammatory responses. The findings underscore the potential of Malaysian herbs in cancer prevention by modulating the polyamine pathway. Universiti Putra Malaysia 2023-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/109954/7/109954_The%20roles%20of%20polyamines%20in%20Malaysian%20herbs%20as%20a%20chemoprevention.pdf application/pdf en http://irep.iium.edu.my/109954/13/109954_The%20roles%20of%20polyamines%20in%20Malaysian%20herbs%20as%20a%20chemoprevention%20strategy%20A%20scoping%20review_Scopus.pdf Azalan, Maryam Syahidah and Abdul Ghani, Radiah and Wallace, Heather M. (2023) The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review. Asia Pacific Journal of Molecular Biology and Biotechnology, 31 (4). pp. 82-95. ISSN 0128-7451 E-ISSN 2672-7277 https://www.scimagojr.com/journalsearch.php?q=14964&tip=sid&clean=0 https://doi.org/10.35118/apjmbb.2023.031.4.09 |
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QP Physiology RM Therapeutics. Pharmacology Azalan, Maryam Syahidah Abdul Ghani, Radiah Wallace, Heather M. The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review |
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Maintaining normal polyamine levels is crucial for the physiological cellular process and differentiation because an imbalance of polyamine concentration affects the occurrence of neoplastic activities in many types of cancer diseases. Malaysian herbs have been purported to have anticancer
properties that influence the polyamine’s bioavailability, leading to cancer cell death. Presently, the roles of polyamines in Malaysian herbs as chemoprevention have yet to be documented. Thus, this review aims to determine which Malaysian herbs have chemoprevention properties affecting polyamines and appraise the relationship between polyamine levels and Malaysian herbs and their cytotoxicity on cancer cells. The search, employing keywords like “Malaysian herbs”, “polyamines”, and “anticancer” or “chemoprevention”, yielded 256 articles. The articles were screened for their eligibility, befitting the objectives mentioned. The PRISMA-ScR checklist was employed to report the published findings from
the databases. Thirteen articles meeting inclusion criteria were selected, highlighting 13 Malaysian herbs influencing the intracellular polyamines pathway. All herbs showed a significant reduction in ornithine decarboxylase (ODC) expression. In addition, Alpinia galanga and Aloe barbadensis showed an increase in catabolic polyamines expression, spermidine/spermine-N-acetyl transferase (SSAT) and spermine oxidase (SMO), respectively, leading to growth arrest and induction of apoptosis in cancer cells. The in vitro and in vivo studies demonstrated these herbs’ anti-proliferative effects on diverse cancer types, involving
polyamine level modulation, intracellular dynamics, and chemopreventive mechanisms through apoptosis
and anti-inflammatory responses. The findings underscore the potential of Malaysian herbs in cancer prevention by modulating the polyamine pathway. |
format |
Article |
author |
Azalan, Maryam Syahidah Abdul Ghani, Radiah Wallace, Heather M. |
author_facet |
Azalan, Maryam Syahidah Abdul Ghani, Radiah Wallace, Heather M. |
author_sort |
Azalan, Maryam Syahidah |
title |
The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review |
title_short |
The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review |
title_full |
The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review |
title_fullStr |
The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review |
title_full_unstemmed |
The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review |
title_sort |
roles of polyamines in malaysian herbs as a chemoprevention strategy: a scoping review |
publisher |
Universiti Putra Malaysia |
publishDate |
2023 |
url |
http://irep.iium.edu.my/109954/7/109954_The%20roles%20of%20polyamines%20in%20Malaysian%20herbs%20as%20a%20chemoprevention.pdf http://irep.iium.edu.my/109954/13/109954_The%20roles%20of%20polyamines%20in%20Malaysian%20herbs%20as%20a%20chemoprevention%20strategy%20A%20scoping%20review_Scopus.pdf http://irep.iium.edu.my/109954/ https://www.scimagojr.com/journalsearch.php?q=14964&tip=sid&clean=0 https://doi.org/10.35118/apjmbb.2023.031.4.09 |
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13.18916 |