Design and synthesis of 1-sec/tert-Butyl-2-Chloro/Nitrophenylbenzimidazole derivatives: molecular docking and in vitro evaluation against MDA-MB-231 and MCF-7 cell lines

• Main Authors: Abdullah, Mar'iyah Najihah, Abd Hamid, Shafida, Muhamad Salhimi, Salizawati, Jalil, Nurul Awani Syazzira, Al-Amin, Mohammad, Jumali, Nor Saliyana
• Format: Article
• Language: English
• Published: Elsevier 2022
• Subjects: QD Chemistry; RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/103152/2/103152_Design%20and%20synthesis%20of%201-sec.pdf; http://irep.iium.edu.my/103152/; https://www.sciencedirect.com/science/article/abs/pii/S0022286022024747?via%3Dihub; https://doi.org/10.1016/j.molstruc.2022.134828

Breast cancer is the most common type of cancer among women and the increasing cases of drug resistance pose a great challenge in the development of new anticancer drugs. Benzimidazole derivatives containing various functional groups have been reported to exhibit excellent anticancer activity. Previ...