Layer-by-Layer Self-Assembled Dynamic Microcapsules (DynaMicCaps) with Polymer and Protein Shell-walls
Triggered delivery is one of the key areas of ongoing research in the field of drug delivery. To achieve triggered drug delivery, a variety of stimuli have been used including light, heat, ultrasound, magnetic field, pH, chemical species, etc. The Murphy group Bioinspired Materials Lab (BML) at...
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| Main Authors: | , , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/908/1/FH03-FBIM-17-08945.pdf http://eprints.unisza.edu.my/908/ |
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| Summary: | Triggered delivery is one of the key areas of
ongoing research in the field of drug delivery.
To achieve triggered drug delivery, a variety of
stimuli have been used including light, heat,
ultrasound, magnetic field, pH, chemical species, etc. The Murphy group Bioinspired Materials Lab (BML) at UW-Madison has demonstrated biochemical ligand triggered drug delivery from PEG-CaM-PEG (PEG- Poly(ethylene
glycol), CaM-Calmodulin) hydrogel slabs and
microspheres based on the nanoscale conformational changes of hinge motion protein calmodulin (King, Mohammed, & Murphy, 2009; King,
Pytel, Ng, & Murphy, 2010). To our knowledge,
there has been no report of triggered drug delivery from dynamic microcapsules. This work
presents fabrication (refer to Figure 1) and preliminary results of layer-by-layer (LbL) selfassembled dynamic microcapsules (DynaMicCaps) whose multilayered shell-walls are comprised of polyelectrolytes (polymers whose repeating units bear an electrolyte group) and
CaM. It is anticipated that the triggered volume
changes in the nano-engineered hollow microcarriers, DynaMicCaps, can be used in triggered
drug release applications. |
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