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Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng

Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2–4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensiv...

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Main Authors: Abdul Manaf, Ali, Siow-Ping, Tan, Mohd Azlan, Nafiah
Format: Article
Language:English
English
Published: Elsevier Science 2015
Subjects:
QD Chemistry
Online Access:http://eprints.unisza.edu.my/6030/1/FH02-FBIM-15-03474.jpg
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http://eprints.unisza.edu.my/6030/
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spelling my-unisza-ir.60302022-09-13T05:10:32Z http://eprints.unisza.edu.my/6030/ Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng Abdul Manaf, Ali Siow-Ping, Tan Mohd Azlan, Nafiah QD Chemistry Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2–4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensive spectroscopic analysis. Murrastinine-C (4) and murrayatanine-A (5) exhibited cytotoxic activity against HL-60 and HeLa (CD50<20 μg/mL) via MTT assay. Elsevier Science 2015 Article PeerReviewed image en http://eprints.unisza.edu.my/6030/1/FH02-FBIM-15-03474.jpg image en http://eprints.unisza.edu.my/6030/2/FH02-FBIM-15-04198.jpg Abdul Manaf, Ali and Siow-Ping, Tan and Mohd Azlan, Nafiah (2015) Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng. Tetrahedron, 71 (23). pp. 3946-3953. ISSN 0040-4020
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
English
topic QD Chemistry
spellingShingle QD Chemistry
Abdul Manaf, Ali
Siow-Ping, Tan
Mohd Azlan, Nafiah
Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
description Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2–4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensive spectroscopic analysis. Murrastinine-C (4) and murrayatanine-A (5) exhibited cytotoxic activity against HL-60 and HeLa (CD50<20 μg/mL) via MTT assay.
format Article
author Abdul Manaf, Ali
Siow-Ping, Tan
Mohd Azlan, Nafiah
author_facet Abdul Manaf, Ali
Siow-Ping, Tan
Mohd Azlan, Nafiah
author_sort Abdul Manaf, Ali
title Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
title_short Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
title_full Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
title_fullStr Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
title_full_unstemmed Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng
title_sort isolation and cytotoxic investigation of new carbazole alkaloids from murraya koenigii (linn.) spreng
publisher Elsevier Science
publishDate 2015
url http://eprints.unisza.edu.my/6030/1/FH02-FBIM-15-03474.jpg
http://eprints.unisza.edu.my/6030/2/FH02-FBIM-15-04198.jpg
http://eprints.unisza.edu.my/6030/
_version_ 1744358546821087232
score 13.211869

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